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1.
Cancer Research, Statistics, and Treatment ; 5(3):592, 2022.
Article in English | EMBASE | ID: covidwho-20244178
2.
Asian Journal of Pharmaceutical and Clinical Research ; 16(5):66-69, 2023.
Article in English | EMBASE | ID: covidwho-20243183

ABSTRACT

Objectives: The objectives of the study was to assess the level of work satisfaction, assess compliance of using PPE among shop assistants during COVID-19 and to find the factors influencing work satisfaction. Method(s): A quantitative approach with descriptive design was used for the study. Eighty samples were selected by using convenient sampling technique. The study was conducted in 4 districts of Kerala through online platform as well as through offline mediums. Result(s): From the study, it is evident that majority of the subjects (55%) were satisfied with their work at the time of COVID-19 and more than half (55%) of the samples have enough compliance with the use of PPE and only 7.5% have less compliance with the use of PPE. Demographic variables such age, relationship status, and work experience were found to be statically significant (p<0.05) with work satisfaction, and other variables did not have a significant association. Conclusion(s): This study provides a baseline for assessing the level of work satisfaction and compliance of PPE among shop assistants in selected areas. Periodic reinforcements, proper education, availability and trainings on the use of PPE can reduce the spread of Corona Virus and improve PPE compliance to an extend. Good working environment support from family and good rapport with colleagues can help to improve work satisfaction .Copyright © 2023 The Authors.

3.
Cancer Research, Statistics, and Treatment ; 5(2):205-211, 2022.
Article in English | EMBASE | ID: covidwho-20235917

ABSTRACT

Background: Patients with cancer are vulnerable to coronavirus disease 2019 (COVID-19). Given the rising number of COVID-19 cases and relaxation of stringent COVID-19 protocols, assessment of the level of protective immunity to COVID-19 in patients with cancer has assumed importance. Objective(s): Our primary objective was to evaluate the seroprevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies in patients with cancer. Material(s) and Method(s): We conducted a cross-sectional study on 100 patients with solid tumors attending our Oncology Department at the Believers Church Medical College, Kerala, India, between December 2020 and June 2021. Seroprevalence was assessed using the VITROS Anti-SARS-CoV-2 IgG test (Ortho-Clinical Diagnostics, Rochester, NY, USA). Additionally, we assessed the factors associated with seropositivity and collected data regarding the general experience of patients with cancer during the pandemic. Result(s): The median age of the participants was 62 years (IQR, 53-69.8);52 (52%) were males. The seroprevalence of the SARS-CoV-2 IgG antibodies was 11% (95% CI, 4.8-17.1). Age < 50 years was the only factor that was significantly associated with a higher rate of COVID-19 antibodies (77% vs 8.9% in patients >= 50 years;P = 0.007), and sex, smoking, and the use of alcohol did not show any association. The majority (77/100, 77%) of the patients were worried about contracting COVID-19 infection;some even deferred cancer-directed treatment because of the fear of visiting health care settings. Conclusion(s): Low seroprevalence of SARS-CoV-2 IgG antibodies in unvaccinated patients with cancer is a matter of concern as it indicates that many of these patients are still vulnerable to infection. There is an urgent need to continue implementing strict safety measures in oncology centers and to encourage widespread COVID-19 vaccination to prevent the uncontrolled spread of COVID-19 among patients with cancer. (Funded by the institution, Believers Church Medical College, Kerala).Copyright © 2023 Neurology India, Neurological Society of India Published by Wolters Kluwer - Medknow.

4.
World Christianity and Covid-19: Looking Back and Looking Forward ; : 35-46, 2022.
Article in English | Scopus | ID: covidwho-20235916

ABSTRACT

In January 2020, foreboding signs of what we now call the COVID-19 pandemic emerged as a threat to global public health, and within a month, fears of an outbreak in New York City were increasingly real. By mid-March 2020, New York City, where we are located, shut down. For a time, the city became the epicenter of this pandemic, bringing unspeakable loss of life. Hundreds of thousands of deaths from COVID-19 have been recorded in New York City, more than one out of five total deaths from the virus in the United States. Sustained by the Spirit is a project developed by City Seminary of New York to listen to what is taking place on the ground, particularly among African, Asian, and Latin American churches in our city during the COVID-19 pandemic. In this proposed paper, we will report on how churches are lamenting what has been lost, what they have missed, and how lament forms the seeds of a new social beginning. This is especially for new ministries mobilized to care for vulnerable populations, those facing job loss and economic precarity, and families caring for children home from school and parents working from home. We will also be reflecting on lament in our Harlem neighborhood, and the impact of losses. This also touches on the area of life, community, pastoral care, and cities. From the interviews and site visits, we developed case studies for a more detailed portrait of this sample of churches and pastoral ministry. With the killing of George Floyd, New York City has become a center of protest and lament, which has its own liturgical life. Instead of the singular COVID-19 pandemic, churches speak of the pandemic of racism as well, another layer of lament. Given that both the public health crisis and our research are still in process, we are not ready to state more than descriptive and emergent findings. However, facing new questions while amid change is a normative experience for the global churches of New York City. In our observation, they have adapted well, continuing to be innovative and agile out of necessity. The churches are making a difference in the everyday lives of New Yorkers, the very fabric and future of the city. And they are lamenting losses that continue to press upon the city. © The Editor(s) (if applicable) and The Author(s), under exclusive licence to Springer Nature Switzerland AG 2023.

5.
Cureus ; 15(5): e38900, 2023 May.
Article in English | MEDLINE | ID: covidwho-20244348

ABSTRACT

Background During the coronavirus disease 2019 (COVID-19) pandemic, telemedicine has provided new means of patient care while still allowing for physical examination and history to be obtained. Hip ailments are a common musculoskeletal problem leading to limited function. Today, we lack a standardized telemedicine hip evaluation protocol. Aim The aim of this manuscript is to provide an efficient means of extracting relevant information while performing telemedicine examinations of the hip. Methods The authors have created a step-by-step evaluation guide for physicians to evaluate hip complaints, including inspection, palpation, range of motion, strength testing, functional assessment, gait analysis, and special testing, with images of each maneuver. Results  We have developed a table of evaluation questions and instructions and a glossary of images of each maneuver to facilitate hip examination via telemedicine. Conclusions This manuscript provides a structured template for performing a telehealth examination of hip ailments.

6.
Foot Ankle Spec ; : 19386400231173836, 2023 Jun 07.
Article in English | MEDLINE | ID: covidwho-20232520

ABSTRACT

A virtual medical visit, also known as telemedicine or telehealth, is a valuable alternative method of providing health care to patients who do not have easy access to a hospital, or during times when limited social interaction is crucial such as our current COVID-19 pandemic. A virtual approach to evaluating musculoskeletal system ailments is particularly challenging, for diagnosis of these conditions generally rely greatly on physical examination, which may be challenging. However, a properly planned and executed telemedicine visit will yield successful results in most cases. Our aim is to produce a document with instructions and suggestions, including physical examination maneuvers, to help physicians carry out a proper virtual medical visit with patients complaining of ankle musculoskeletal problems. Virtual visits should not be thought of as a replacement for traditional face-to-face medical consultations, but rather a complementary method to provide health care when deemed appropriate. By following this guide, and tailoring it to the specific case at hand, medical providers should be able to effectively carry out a successful telemedicine consultation for musculoskeletal ailments relating to the ankle.Levels of Evidence: Level V.

7.
Indian Journal of Forensic Medicine and Toxicology ; 17(2):32-35, 2023.
Article in English | EMBASE | ID: covidwho-2314142

ABSTRACT

Introducction:-Covid 19 started out as a fast-spreading viral disease, in Wuhan in 2019. Soon, it spread across the globe and WHO declared it a Pandemic. Various countries took various measures to control its spread and transmission. By the time, countries recovered from it, a new wave would come along with different expressions and pathophysiology. When Covid 19 began, various health agencies in India started making protocols and standard ooperating procedures including conducting autopsies in COVID-19 infected bodies. Aims and Objectives:-Aim of our study is to analyze cause of death among all covid 19 positive cases brought for medicolegal autopsies from the time of lockdown for a period of one year. Our aim is to see if there were any factors which could have prevented these deaths. Material(s) and Method(s): A retrospective study of 1 year conducted from 25th March 2020 to 24th March 2021, (1st wave of Covid 19) was done in a tertiary care hospital in Bangalore. (Bowring and Lady Curzon hospital) Results: 39 Covid-19-positive unnatural deaths were handled with the youngest being 18 years old and the oldest beings 83. The majority turned out to be suicides (51.28%), then RTAs, falls, and natural death. The commonest method of suicide was hanging (35.89%), followed by poison consumption, and falling from a height. Conclusion(s): COVID-19 is a viral infection with variable clinical signs and variable fatality rates. There is much to learn about it. However, suicides in COVID-19 cases might not have ended death if some care, timely diagnosis, and treatment were provided.Copyright © 2023, Institute of Medico-legal Publication. All rights reserved.

8.
J Antimicrob Chemother ; 78(Suppl 1): i17-i25, 2023 05 03.
Article in English | MEDLINE | ID: covidwho-2312169

ABSTRACT

OBJECTIVES: To investigate the levels of MDR in the predominant serotypes of invasive Streptococcus pneumoniae isolated in Canada over a 10 year period. METHODS: All isolates were serotyped and had antimicrobial susceptibility testing performed, in accordance with CLSI guidelines (M07-11 Ed., 2018). Complete susceptibility profiles were available for 13 712 isolates. MDR was defined as resistance to three or more classes of antimicrobial agents (penicillin MIC ≥2 mg/L defined as resistant). Serotypes were determined by Quellung reaction. RESULTS: In total, 14 138 invasive isolates of S. pneumoniae were tested in the SAVE study (S. pneumoniae Serotyping and Antimicrobial Susceptibility: Assessment for Vaccine Efficacy in Canada), a collaboration between the Canadian Antimicrobial Resistance Alliance and Public Health Agency of Canada-National Microbiology Laboratory. The rate of MDR S. pneumoniae in SAVE was 6.6% (902/13 712). Annual rates of MDR S. pneumoniae decreased between 2011 and 2015 (8.5% to 5.7%) and increased between 2016 and 2020 (3.9% to 9.4%). Serotypes 19A and 15A were the most common serotypes demonstrating MDR (25.4% and 23.5% of the MDR isolates, respectively); however, the serotype diversity index increased from 0.7 in 2011 to 0.9 in 2020 with a statistically significant linear increasing trend (P < 0.001). In 2020, MDR isolates were frequently serotypes 4 and 12F in addition to serotypes 15A and 19A. In 2020, 27.3%, 45.5%, 50.5%, 65.7% and 68.7% of invasive MDR S. pneumoniae were serotypes included in the PCV10, PCV13, PCV15, PCV20 and PPSV23 vaccines, respectively. CONCLUSIONS: Although current vaccine coverage of MDR S. pneumoniae in Canada is high, the increasing diversity of serotypes observed among the MDR isolates highlights the ability of S. pneumoniae to rapidly evolve.


Subject(s)
Pneumococcal Infections , Streptococcus pneumoniae , Humans , Serogroup , Pneumococcal Infections/microbiology , Anti-Bacterial Agents/pharmacology , Canada/epidemiology , Microbial Sensitivity Tests , Serotyping , Pneumococcal Vaccines
9.
Cureus ; 15(4): e37009, 2023 Apr.
Article in English | MEDLINE | ID: covidwho-2320223

ABSTRACT

Introduction The coronavirus disease 2019 (COVID-19) pandemic has resulted in rapid healthcare system adaptations, including the acceptance of telemedicine in primary care. In the case of knee ailments, among the most common problems encountered in primary care, telemedicine provides a literal window to observe the patient performing functional activities. Despite its potential, there is a lack of standardized protocols for data collection. The purpose of this article is to provide a step-by-step protocol to aid in performing a telemedicine examination of the knee. Methods This article provides a step-by-step guide for a telehealth examination of the knee. Results A step-by-step examination of how to structure a telemedicine evaluation of the knee. A glossary of images of each maneuver has been included to demonstrate the components of the examination. Additionally, a table of questions and possible answers were included to help guide the provider through a knee examination. Conclusion This article provides a structured and efficient means of extracting clinically relevant information during telemedicine examinations of the knee.

10.
Acs Es&T Water ; 2023.
Article in English | Web of Science | ID: covidwho-2307089

ABSTRACT

Aquatic ecosystems of tropical countries are vulnerable to fecal contamination that could cause spikes in the incidences of acute diarrheal disease (ADD) and challenge public health management systems. Vembanad lake, situated along the southwest coast of India, was monitored for one year (2018-2019). Escherichia coli, an indicator of fecal contamination, was prevalent in the lake throughout the year. Multiple antibiotic resistance among more than 50% of the E. coli isolates adds urgency to the need to control this contamination. The high abundance of E. coli and incidence of ADD were recorded during the early phase of the southwest monsoon (June-July), prior to the once-in-a-century floods that affected the region in the later phase (August). The extent of inundation in the low-lying areas peaked in August, but E. coli in the water peaked in July, suggesting that contamination occurred even prior to extreme flooding. During the COVID-19-related lockdown in March-May 2021, fecal contamination in the lake and incidence of ADD reached minimum values. These results indicate the need for improving sewage treatment facilities and city planning in flood-prone areas to avoid the mixing of septic sewage with natural waters during extreme climate events or even during the normal monsoon.

12.
Health Sci Rep ; 6(4): e1218, 2023 Apr.
Article in English | MEDLINE | ID: covidwho-2301607

ABSTRACT

According to WHO, Ukraine has the fourth-highest Tuberculosis (TB) incidence in the WHO European region while globally has the fifth-highest number of confirmed cases of extensively drug-resistant TB. Before the Russian invasion in Ukraine several interventions have been employed to mitigate the TB epidemic in the country. However, the ongoing war has demolished meticulous efforts and subsequently worsen the situation. WHO in collaboration with the Ukraine government and other organizations such as EU and UK are required to take up arms against the situation. In this work, implications brought up from the war, efforts, and recommendations to battling TB epidemic due to the war are highlighted.

13.
Quarterly Journal of the Royal Meteorological Society ; 2023.
Article in English | Scopus | ID: covidwho-2277739

ABSTRACT

Since March 2020, the COVID-19 pandemic has significantly reduced the availability of global aircraft-based observations (ABOs), which has been restored later in 2021. This study focuses on the impact of ABOs on a regional reanalysis. Indian Monsoon Data Assimilation and Analysis (IMDAA) is a regional reanalysis for a period from 1979 to 2020 (originally up to 2018) over India and surrounding regions produced at the National Centre for Medium Range Weather Forecasting (NCMRWF), India, in collaboration with the UK Met Office. A comparison of the impact of ABOs on other conventional and satellite observations assimilated in the NCMRWF global model and IMDAA during 2019 and 2020 revealed the importance of ABOs, particularly in IMDAA, since it did not assimilate the latest satellite data as the IMDAA system was frozen in October 2016. A data denial experiment that removes all the ABOs from the IMDAA assimilation system for a period from March to November 2019 is designed. The results from the IMDAA reanalysis run, which assimilates ABOs during the same period, are compared with the data denial experiment. Assimilation of ABOs strengthened the upper tropospheric circulation, the Tropical Easterly Jet (TEJ), during the Indian summer monsoon compared to the data denial experiment. Analysis of the features of two cyclones that developed over the North Indian Ocean during the study period revealed that ABO assimilation played a key role in simulating the track and intensity of these cyclones when they were in the ‘severe' category. Since the sample is small, more cyclone cases need to be analysed to consolidate the result. © 2023 Royal Meteorological Society.

14.
Cureus ; 15(2): e35322, 2023 Feb.
Article in English | MEDLINE | ID: covidwho-2285723

ABSTRACT

BACKGROUND:  The COVID-19 pandemic has highlighted the utility of telemedicine, with rapid incorporation throughout 2020. Telemedicine is a timely, safe, and effective means of evaluating, triaging, and treating patient conditions, including those of the musculoskeletal system. Hand and wrist complaints are frequently encountered in the primary care setting, and some can have serious consequences if not promptly diagnosed. Prior to the pandemic, over a quarter of the nation's allopathic degree-granting medical schools had initiated telemedicine training as part of the preclinical phase of their curriculum, and about half had implemented it into clerkships prior to the pandemic. Despite rapid acceptance, increased ease of access, and prior attempts to incorporate telemedicine into the educational curriculum, telemedicine evaluation continues to pose challenges to both the patient and provider. This is likely due to a lack of established protocols outlining clinical data collection through a virtual interface. Although telemedicine requires the patient to perform a physical examination, it allows the physician to collect clinically important information while observing the patient in their home environment. AIMS:  The aim of this paper is to provide a step-by-step method to evaluate and triage hand and wrist complaints. METHODS:  Our group has created a step-by-step evaluation pathway to help physicians direct their patients through typical hand and wrist examination elements, including inspection, palpation, range of motion (ROM), strength, special, and functional testing. RESULTS:  We have developed a table of evaluation questions and instructions and a glossary of images of each maneuver to facilitate hand and wrist examination via telemedicine. CONCLUSION:  This paper provides a guide for extracting clinically relevant information while performing telemedicine examinations of the hand.

15.
J Addict Med ; 2023 Mar 02.
Article in English | MEDLINE | ID: covidwho-2269715

ABSTRACT

OBJECTIVE: The coronavirus disease 2019 (COVID-19) pandemic necessitated changes in opioid use disorder care. Little is known about COVID-19's impact on general healthcare clinicians' experiences providing medication treatment for opioid use disorder (MOUD). This qualitative evaluation assessed clinicians' beliefs about and experiences delivering MOUD in general healthcare clinics during COVID-19. METHODS: Individual semistructured interviews were conducted May through December 2020 with clinicians participating in a Department of Veterans Affairs initiative to implement MOUD in general healthcare clinics. Participants included 30 clinicians from 21 clinics (9 primary care, 10 pain, and 2 mental health). Interviews were analyzed using thematic analysis. RESULTS: The following 4 themes were identified: overall impact of the pandemic on MOUD care and patient well-being, features of MOUD care impacted, MOUD care delivery, and continuance of telehealth for MOUD care. Clinicians reported a rapid shift to telehealth care, resulting in few changes to patient assessments, MOUD initiations, and access to and quality of care. Although technological challenges were noted, clinicians highlighted positive experiences, including treatment destigmatization, more timely visits, and insight into patients' environments. Such changes resulted in more relaxed clinical interactions and improved clinic efficiency. Clinicians reported a preference for in-person and telehealth hybrid care models. CONCLUSIONS: After the quick shift to telehealth-based MOUD delivery, general healthcare clinicians reported few impacts on quality of care and highlighted several benefits that may address common barriers to MOUD care. Evaluations of in-person and telehealth hybrid care models, clinical outcomes, equity, and patient perspectives are needed to inform MOUD services moving forward.

16.
ACS ES and T Water ; 2022.
Article in English | Scopus | ID: covidwho-2227006

ABSTRACT

Aquatic ecosystems of tropical countries are vulnerable to fecal contamination that could cause spikes in the incidences of acute diarrheal disease (ADD) and challenge public health management systems. Vembanad lake, situated along the southwest coast of India, was monitored for one year (2018-2019). Escherichia coli, an indicator of fecal contamination, was prevalent in the lake throughout the year. Multiple antibiotic resistance among more than 50% of the E. coli isolates adds urgency to the need to control this contamination. The high abundance of E. coli and incidence of ADD were recorded during the early phase of the southwest monsoon (June-July), prior to the once-in-a-century floods that affected the region in the later phase (August). The extent of inundation in the low-lying areas peaked in August, but E. coli in the water peaked in July, suggesting that contamination occurred even prior to extreme flooding. During the COVID-19-related lockdown in March-May 2021, fecal contamination in the lake and incidence of ADD reached minimum values. These results indicate the need for improving sewage treatment facilities and city planning in flood-prone areas to avoid the mixing of septic sewage with natural waters during extreme climate events or even during the normal monsoon. © 2023 American Chemical Society.

17.
Technol Health Care ; 2022 Aug 03.
Article in English | MEDLINE | ID: covidwho-2236704

ABSTRACT

BACKGROUND: Telehealth evaluations of musculoskeletal conditions have increased due to the stay-at-home policies enacted during the COVID-19 pandemic. Back pain is one of the most common complaints in primary care. While telehealth may never supplant in-person evaluation of back pain, it is imperative in a changing world to learn to perform this evaluation via telephone or video. Virtual visits rely on history-taking and patient self-reported descriptions of pain elicited from self-palpation or specific movements while on the telephone with the clinician. Video examinations provide a unique way of evaluating the lower back compared to telephone because of the ability to visualize the actions of the patient. OBJECTIVE: To create an evaluation pathway for examination of the lumbar spine via telehealth. METHODS: Our group has created a step-by-step evaluation pathway to help physicians direct their patients through typical lumbar examination elements, including inspection, palpation, range of motion, and strength, special, and functional testing. RESULTS: We have developed a table of questions and instructions and a glossary of images of each maneuver to facilitate lumbar spine examination via telemedicine. CONCLUSIONS: This paper provides a guide for extracting clinically relevant information while performing telemedicine examinations of the lumbar spine.

19.
Research and Practice in Thrombosis and Haemostasis Conference ; 6(Supplement 1), 2022.
Article in English | EMBASE | ID: covidwho-2128086

ABSTRACT

Background: Some COVID-19 vaccinated individuals develop anti-platelet factor 4 (PF4) antibodies that cause thrombocytopenia and thrombosis;a rare syndrome referred to as vaccine-induced immune thrombotic thrombocytopenia (VITT). Currently, information on the characteristics and persistence of anti-PF4 antibodies that cause VITT after Ad26.COV2.S vaccination is limited, and available PF4-polyanion enzyme-linked immunosorbent assays (ELISAs) and functional diagnostic assays fail to differentiate Ad26.COV2.S and ChAdOx1 nCoV-19-associated VITT from similar clinical disorders, namely heparin-induced thrombocytopenia (HIT) and spontaneous HIT. Aim(s): Evaluate the persistence of anti-PF4 antibodies in Ad26. COV2.S-associated VITT and correlate findings with clinical and laboratory variables such as thrombosis and platelet counts. Develop/ investigate laboratory tools that differentiate VITT antibodies from HIT and spontaneous HIT. Method(s): Blood samples from VITT and HIT patient cohorts were tested in antigen-based and functional assays and correlated with clinical and laboratory features. Result(s): While Ad26.COV2.S-associated VITT patients were strongly positive in PF4-polyanion ELISAs;they were frequently negative in the serotonin release assay (4 of 8 tested patients were negative). In contrast, the PF4-dependent p-selectin expression assay (PEA) that uses PF4-treated platelets consistently diagnosed Ad26.COV2.S-associated VITT. Most Ad26.COV2.S-associated VITT antibodies persisted for >5 months in PF4-polyanion ELISAs, while the PEA became negative earlier. Two patients had otherwise unexplained mild persistent thrombocytopenia (140-150,000/ mul) six months after acute presentation. No recurrence of thrombosis was noted. Additionally, a novel un-complexed PF4 ELISA specifically differentiated VITT secondary to Ad26.COV2.S and ChAdOx1 nCoV-19 vaccination, from spontaneous HIT and HIT (Fig 1A-PF4/ polyanion ELISA;Fig 1B-Un-complexed PF4 ELISA;closed black circles-Ad26. COV2.S-associated VITT;closed red circle-ChAdOx1 nCoV-19-associated VITT;***p < 0.001;****p < 0.0001). Its specificity was further confirmed by testing commonly-encountered HIT-suspected patient samples that are PF4/polyanion ELISA-positive but negative in functional assays (1A-1B). Conclusion(s): Ad26.COV2.S-associated VITT antibodies are persistent, and the un-complexed PF4 ELISA appears to be both sensitive and specific for VITT diagnosis.

20.
Tanzania Journal of Health Research ; 23(Supplement 1):77, 2022.
Article in English | EMBASE | ID: covidwho-2114816

ABSTRACT

Background: Given the ongoing spread of COVID-19 and relatively low uptake of vaccines in Tanzania, there is an opportunity to develop strategies for gathering community input to inform public health responses to disease outbreaks, and vaccine deployment strategies. Objective(s): To provide evidence about COVID-19 to response teams through integration of social science methods in the community engagement strategy to strengthen preventive and control interventions and vaccine deployment in Tanzania. The objectives are: 1) To document knowledge, beliefs, rumours, and discussions related to COVID-19, prevention and control measures, vaccines, and vaccine deployment 2) To identify information that needs action by the COVID-19 response teams at district and national levels 3) To examine the effectiveness of using community health workers in collecting evidence to inform epidemic response teams Methodology: This project trained 22 CHWs in Dar es Salaam, Pwani and Kigoma Regions in social science methods and research ethics. The CHWs then documented the challenges, rumours, beliefs, (mis)information, feelings/emotions, and intentions of community members in their jurisdictions during their routine daily work in health promotion for COVID-19 vaccines. We also conducted semi-structured interviews with village, district, regional and national leaders and health officials on their experience working in COVID-19 vaccine deployment. Result(s): Analysis using the WHO Determinants of Vaccine Hesitancy Matrix showed that while hesitancy in various Tanzanian communities is linked to broader historical and socio-political narratives (e.g., colonialism, racism, national politics), hesitancy around COVID-19 vaccines is overwhelmingly vaccine-specific and confidence in routine vaccinations appears to remain high. Community members, leaders and CHWs themselves have doubts and questions about vaccine safety and efficacy. Conclusions and recommendations: There is an opportunity to implement education campaigns around COVID-19 vaccines that are directly responsive to documented doubts and questions to build vaccine confidence in Tanzania.

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